Fingerprint Spectroscopic SRS Imaging of Single Living Cells and Whole Brain by Ultrafast Tuning and Spatial-Spectral Learning

  title={Fingerprint Spectroscopic SRS Imaging of Single Living Cells and Whole Brain by Ultrafast Tuning and Spatial-Spectral Learning},
  author={Haonan Lin and Hyeon Jeong Lee and Nathan Tague and Jean-Baptiste Lugagne and Cheng Zong and Fengyuan Deng and Wilson Wong and Mary J. Dunlop and Ji‐Xin Cheng},
  journal={arXiv: Medical Physics},
Label-free vibrational imaging by stimulated Raman scattering (SRS) provides unprecedented insight into real-time chemical distributions in living systems. Specifically, SRS in the fingerprint region can resolve multiple chemicals in a complex bio-environment using specific and well-separated Raman signatures. Yet, fingerprint SRS imaging with microsecond spectral acquisition has not been achieved due to the small fingerprint Raman cross-sections and the lack of ultrafast acquisition scheme… 

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Ovarian cancer cell fate regulation by the dynamics between saturated and unsaturated fatty acids.

  • Guangyuan ZhaoYuying Tan D. Matei
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2022
Fatty acids are an important source of energy and a key component of phospholipids in membranes and organelles. Saturated fatty acids (SFAs) are converted into unsaturated fatty acids (UFAs) by

Bringing Vibrational Imaging to Chemical Biology with Molecular Probes.

The development of biorthogonal SRS imaging using small tagging of triple bonds or isotopes is discussed and their unique advantages for metabolic pathway analysis and microbiology investigations are highlighted.

Deep learning in light–matter interactions

The emerging opportunities and challenges of deep learning in photonics are discussed, shining light on how deep learning advances photonics.

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Spectroscopic stimulated Raman scattering imaging of highly dynamic specimens through matrix completion

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Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering

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Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy

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Quantitative vibrational imaging by hyperspectral stimulated Raman scattering microscopy and multivariate curve resolution analysis.

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Label-Free Vibrational Spectroscopic Imaging of Neuronal Membrane Potential.

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