Fine-tuning somatostatin receptor signalling by agonist-selective phosphorylation and dephosphorylation: IUPHAR Review 5.

@article{Schulz2014FinetuningSR,
  title={Fine-tuning somatostatin receptor signalling by agonist-selective phosphorylation and dephosphorylation: IUPHAR Review 5.},
  author={Stefan Schulz and Andreas Lehmann and Andrea rer. nat. Kliewer and Falko rer. nat. Nagel},
  journal={British journal of pharmacology},
  year={2014},
  volume={171 7},
  pages={
          1591-9
        }
}
The biological actions of somatostatin are mediated by a family of five GPCRs, named sst1 to sst5 . Somatostatin receptors exhibit equally high-binding affinities to their natural ligand somatostatin-14 and largely overlapping distributions. The overexpression of somatostatin receptors in human tumours is the molecular basis for diagnostic and therapeutic application of the stable somatostatin analogues octreotide, lanreotide and pasireotide. The efficiency of somatostatin receptor signalling… CONTINUE READING
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