Fine tuning of growth factor signals depends on fibrillin microfibril networks.

@article{Charbonneau2004FineTO,
  title={Fine tuning of growth factor signals depends on fibrillin microfibril networks.},
  author={Noe L. Charbonneau and Robert N. Ono and Glen M. Corson and Douglas R. Keene and Lynn Y. Sakai},
  journal={Birth defects research. Part C, Embryo today : reviews},
  year={2004},
  volume={72 1},
  pages={37-50}
}
Growth factors, potent regulators of cell differentiation, tissue morphogenesis, tissue homeostasis, and cellular response to injury, reside in the extracellular matrix. Genetic evidence in humans and mice as well as biochemical data implicate fibrillins and LTBPs in the extracellular control of TGFbeta and BMP signaling. Fibrillins and LTBPs form tissue-specific and temporally regulated microfibril networks. In the developing embryo, three fibrillins and four LTBPs contribute molecular… CONTINUE READING