Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates

@inproceedings{Basch2016FinetuningON,
  title={Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates},
  author={Mart{\'i}n L. Basch and Rogers M Brown and Hsin-I Jen and Fatih Semerci and Frederic F S Depreux and Ren{\'e}e K. Edlund and Hongyuan Zhang and Christine R. Norton and Thomas Gridley and Susan E Cole and Angelika Doetzlhofer and Mirjana Maletic-Savatic and Neil Segil and Andrew K Groves},
  booktitle={eLife},
  year={2016}
}
The signals that induce the organ of Corti and define its boundaries in the cochlea are poorly understood. We show that two Notch modifiers, Lfng and Mfng, are transiently expressed precisely at the neural boundary of the organ of Corti. Cre-Lox fate mapping shows this region gives rise to inner hair cells and their associated inner phalangeal cells. Mutation of Lfng and Mfng disrupts this boundary, producing unexpected duplications of inner hair cells and inner phalangeal cells. This phenotype… CONTINUE READING
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