Fine structure of translocation breakpoints within the major breakpoint region in BCR-ABL1-positive leukemias.

@article{Burmeister2011FineSO,
  title={Fine structure of translocation breakpoints within the major breakpoint region in BCR-ABL1-positive leukemias.},
  author={Thomas Burmeister and Daniela Gr{\"o}ger and Anett K{\"u}hn and Dieter Hoelzer and Eckhard Thiel and Richard Reinhardt},
  journal={DNA repair},
  year={2011},
  volume={10 11},
  pages={1131-7}
}
The chromosomal translocation t(9;22)(q34;q22), with expression of the BCR-ABL1 fusion gene is the cytogenetic and molecular hallmark of chronic myeloid leukemia (CML) and a subset of acute lymphoblastic leukemia (ALL). Basically two types of BCR-ABL1 chimeric mRNA transcripts have been observed: (1) e13a2/e14a2 transcripts in CML and ALL, resulting from chromosomal breaks in the major breakpoint cluster region (M-bcr) of the BCR gene and (2) e1a2 transcripts in ALL resulting from breaks in the… CONTINUE READING