Fine structure of islets of Langerhans in insular amyloidosis

  title={Fine structure of islets of Langerhans in insular amyloidosis},
  author={Per Westermark},
  journal={Virchows Archiv A},
The islets of Langerhans of diabetic and non-diabetic patients with different degrees of islet amyloidosis were studied by electron microscopy. The islet amyloid exhibited the typical fine fibrillar ultrastructure and was mainly located interstitially. Adjacent to the β cells the amyloid fibrils were often highly orientated perpendicularly to the cell surface and bundles of amyloid fibrils entered in deep plasmalemmal invaginations of the cells. This was more rarely seen in other types of cell… CONTINUE READING


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