Fine structure mapping and deletion analysis of the murine piebald locus.

@article{Metallinos1994FineSM,
  title={Fine structure mapping and deletion analysis of the murine piebald locus.},
  author={Danika L. Metallinos and Adam J. Oppenheimer and Eugene M. Rinchik and Liane Brauch Russell and William Dietrich and Shirley M. Tilghman},
  journal={Genetics},
  year={1994},
  volume={136 1},
  pages={217-23}
}
piebald (s) is a recessive mutation that affects the development of two cell types of neural crest origin: the melanocytes, responsible for pigment synthesis in the skin, and enteric ganglia, which innervate the lower bowel. As a result, mice carrying piebald mutations exhibit white spotting in the coat and aganglionic megacolon. Previously the gene had been localized to the distal half of mouse chromosome 14. To determine its precise location relative to molecular markers, an intersubspecific… CONTINUE READING