Fine structure analysis of type-specific and type-common antigenic sites of herpes simplex virus glycoprotein D.

Abstract

The fine structure of the antigenic determinants of herpes simplex virus type 1 and 2 glycoprotein D (gD) was analyzed to determine whether structural differences underlie the differential immunogenicity of these glycoproteins. A region common to herpes simplex virus type 1 and 2 gD (amino acid residues 11 to 19) and two sites specific for herpes simplex virus type 2 gD (one determined by proline at position 7, the other determined by asparagine at position 21) were localized within the N-terminal 23 amino acids of gD by synthesis of peptides and comparison of their cross-reactivity with antisera raised to herpes simplex virus type 1 and 2 gD. The secondary structure of these peptides, as predicted by computer analysis, is discussed in relation to their immunogenicity.

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@article{Dietzschold1984FineSA, title={Fine structure analysis of type-specific and type-common antigenic sites of herpes simplex virus glycoprotein D.}, author={Bernhard Dietzschold and Roselyn J. Eisenberg and Manuel Ponce de Leon and Edward Golub and Ferenc Hudecz and A M Varrichio and Gary Cohen}, journal={Journal of virology}, year={1984}, volume={52 2}, pages={431-5} }