Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis.

@article{Hirano1984FineSO,
  title={Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis.},
  author={Asao Hirano and H. Donnenfeld and Shoichi Sasaki and Imaharu Nakano},
  journal={Journal of neuropathology and experimental neurology},
  year={1984},
  volume={43 5},
  pages={461-70}
}
Twenty-two of 32 sporadic cases of amyotrophic lateral sclerosis had argyrophilic spheroids, 20 micrometers or larger, in the anterior horns of the spinal cords. The fine structure of these spherical bodies was characterized by interwoven, small bundles of 10 nm neurofilaments. Scattered mitochondria, vesicles and fragments of smooth endoplasmic reticulum were commonly found among the bundles of neurofilaments. The spheroids were present not only in the myelinated axons, but also in the… CONTINUE READING

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