Fine structural nature of delayed neuronal death following ischemia in the gerbil hippocampus

@article{Kirino1984FineSN,
  title={Fine structural nature of delayed neuronal death following ischemia in the gerbil hippocampus},
  author={Takaaki Kirino and Keiji Sano},
  journal={Acta Neuropathologica},
  year={1984},
  volume={62},
  pages={209-218}
}
An unusual, delayed neuronal death (DND) has been noticed in the hippocampus of the Mongolian gerbil following brief ischemia (Kirino 1982). On day 1 following 5–10min of ischemia, light microscopy showed the CA1 pyramidal cells unchanged. On day 2, the cells showed massive growth of membranous cytoplasmic organelles instead of overt cellular disintegration. These neurons were destroyed extensively by day 4 after ischemic insult. Following longer ischemia (20–30min), however, the changes in the… CONTINUE READING

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