Fine-structural analysis and connexin expression in the retina of a transgenic model of Huntington's disease.

@article{PetraschParwez2004FinestructuralAA,
  title={Fine-structural analysis and connexin expression in the retina of a transgenic model of Huntington's disease.},
  author={Elisabeth Petrasch-Parwez and Hans-Werner Habbes and Svenja Weickert and Marlen L{\"o}bbecke-Schumacher and Katherine Striedinger and Stefan S Wieczorek and Rolf Dermietzel and J{\"o}rg T. Epplen},
  journal={The Journal of comparative neurology},
  year={2004},
  volume={479 2},
  pages={
          181-97
        }
}
Recent studies indicate that the visual system appears more frequently affected in polyglutamine diseases than expected previously. Here, we investigated retinal degenerations in adult transgenic R6/2 mice, a model for Huntington's disease (HD). Light microscopical analysis revealed retinal dystrophy all over the retina, with central areas showing major effects. Electron microscopical analysis showed strong degenerations of outer and inner photoreceptor segments, shrinkage of photoreceptor cell… CONTINUE READING

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