Fine specificity of serum antibodies to Plasmodium falciparum merozoite surface protein, PfMSP-1(19), predicts protection from malaria infection and high-density parasitemia.

@article{Okech2004FineSO,
  title={Fine specificity of serum antibodies to Plasmodium falciparum merozoite surface protein, PfMSP-1(19), predicts protection from malaria infection and high-density parasitemia.},
  author={Brenda A Okech and Patrick H. Corran and James N Todd and Amy Joynson-Hicks and Chairat Uthaipibull and Thomas G. Egwang and Anthony A. Holder and Eleanor M. Riley},
  journal={Infection and immunity},
  year={2004},
  volume={72 3},
  pages={1557-67}
}
Antibodies to the C terminus of the Plasmodium falciparum merozoite surface protein, PfMSP-1(19), may inhibit merozoite invasion or block the effects of inhibitory antibodies. Here, using a competition enzyme-linked immunosorbent assay and antibody binding to wild-type and mutated recombinant proteins, we show that there are marked variations between individuals in the fine specificity of naturally acquired anti-MSP-1(19) antibodies. Furthermore, although neither the prevalence nor the… CONTINUE READING

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