Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex.

@article{Grant2002FineSO,
  title={Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex.},
  author={Ethan P. Grant and Evan M. Beckman and Samuel M Behar and Massimo Degano and Daphney Frederique and Gurdyal S Besra and Ian A. Wilson and Steven A. Porcelli and Stephen T. Furlong and Michael B Brenner},
  journal={Journal of immunology},
  year={2002},
  volume={168 8},
  pages={3933-40}
}
alphabeta TCR can recognize peptides presented by MHC molecules or lipids and glycolipids presented by CD1 proteins. Whereas the structural basis for peptide/MHC recognition is now clearly understood, it is not known how the TCR can interact with such disparate molecules as lipids. Recently, we demonstrated that the alphabeta TCR confers specificity for both the lipid Ag and CD1 isoform restriction, indicating that the TCR is likely to recognize a lipid/CD1 complex. We hypothesized that lipids… CONTINUE READING