Fine-scale linkage disequilibrium mapping of age-related macular degeneration in the complement factor H gene region.

@article{Ennis2007FinescaleLD,
  title={Fine-scale linkage disequilibrium mapping of age-related macular degeneration in the complement factor H gene region.},
  author={Sarah Ennis and Srini Goverdhan and Angela Jane Cree and Josephine Hoh and Andrew Collins and Andrew J. Lotery},
  journal={The British journal of ophthalmology},
  year={2007},
  volume={91 7},
  pages={966-70}
}
AIM To present results from a nested association study of the complement factor H (CFH) gene region using a novel methodology that uses a high-resolution genetic linkage disequilibrium map to estimate a point location for a causal mutation. METHOD Age-related macular degeneration (AMD) case-control data from a genomewide single-nucleotide polymorphism (SNP) panel were used to identify the target interval to be genotyped at higher density in a second independent panel. The pattern of linkage… CONTINUE READING