Fine-scale chromatin interaction maps reveal the cis-regulatory landscape of human lincRNA genes


High-throughput methods based on chromosome conformation capture have greatly advanced our understanding of the three-dimensional (3D) organization of genomes but are limited in resolution by their reliance on restriction enzymes. Here we describe a method called DNase Hi-C for comprehensively mapping global chromatin contacts. DNase Hi-C uses DNase I for… (More)
DOI: 10.1038/nmeth.3205


5 Figures and Tables