Fine mapping study reveals novel candidate genes for carotid intima-media thickness in Dominican Republican families.

@article{Wang2012FineMS,
  title={Fine mapping study reveals novel candidate genes for carotid intima-media thickness in Dominican Republican families.},
  author={Liyong Wang and Ashley Harris Beecham and Degen Zhuo and C Dong and Susan Halloran Blanton and Tatjana Rundek and Ralph L. Sacco},
  journal={Circulation. Cardiovascular genetics},
  year={2012},
  volume={5 2},
  pages={234-41}
}
BACKGROUND Carotid intima-media thickness (CIMT) is a subclinical measure for atherosclerosis. Previously, we have mapped quantitative trait loci (QTLs) for CIMT to chromosomes 7p (maximum logarithm of odds=3.1) and to 14q (maximum logarithm of odds=2.3). We sought to identify the underlying genetic variants within those QTLs. METHODS AND RESULTS Using the 100 extended Dominican Republican (DR) families (N=1312) used in the original linkage study, we fine mapped the QTLs with 2031 tagging… CONTINUE READING

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