Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity

@inproceedings{HamiltonWilliams2013FineMO,
  title={Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity},
  author={Emma E Hamilton-Williams and Daniel B. Rainbow and Jocelyn Cheung and Mikkel B. Christensen and Paul A. Lyons and Laurence B. Peterson and Charles A. Steward and Linda A Sherman and Linda S. Wicker},
  booktitle={Mammalian Genome},
  year={2013}
}
Nonobese diabetic (NOD) mice congenic for C57BL/10 (B10)-derived genes in the Idd9 region of chromosome 4 are highly protected from type 1 diabetes (T1D). Idd9 has been divided into three protective subregions (Idd9.1, 9.2, and 9.3), each of which partially prevents disease. In this study we have fine-mapped the Idd9.1 and Idd9.2 regions, revealing further genetic complexity with at least two additional subregions contributing to protection from T1D. Using the NOD sequence from bacterial… CONTINUE READING