Fine mapping of the X-linked split-hand/split-foot malformation (SHFM2) locus to a 5.1-Mb region on Xq26.3 and analysis of candidate genes.

@article{FaiyazulHaque2005FineMO,
  title={Fine mapping of the X-linked split-hand/split-foot malformation (SHFM2) locus to a 5.1-Mb region on Xq26.3 and analysis of candidate genes.},
  author={Muhammad Faiyaz-ul-Haque and Syed Hassan Ejaz Zaidi and Louise Marie King and Sayedul Haque and Ms M. B. Patel and M. Ahmad and Teepu Siddique and Wasim Ahmad and L. S. M. Tsui and Daniel H Cohn},
  journal={Clinical genetics},
  year={2005},
  volume={67 1},
  pages={93-7}
}
Split-hand/split-foot malformation (SHFM) is a genetically heterogeneous disorder, with five known loci, that causes a lack of median digital rays, syndactyly, and aplasia or hypoplasia of the phalanges, metacarpals, and metatarsals. In the only known SHFM2 family, affected males and homozygous females exhibit monodactyly or bidactyly of the hands and lobster-claw feet. This family (1) was revisited to include additional subjects and genealogical data. All 39 affected males and three females… CONTINUE READING

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Clinical, genetic, and molecular aspects of split-hand/foot malformation: an update.

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