Fine-mapping of quantitative trait loci in half-sib families using current recombinations.

@article{Thaller2000FinemappingOQ,
  title={Fine-mapping of quantitative trait loci in half-sib families using current recombinations.},
  author={Georg Erwin Thaller and Ina Hoeschele},
  journal={Genetical research},
  year={2000},
  volume={76 1},
  pages={87-104}
}
Two groups of methods are being developed to fine-map quantitative trait loci (QTLs): identity-by-descent methods or methods using historical recombinations, and genetic chromosome dissection methods or methods utilizing current recombinations. Here we propose two methods that fall into the second group: contrast mapping and substitution mapping. A QTL has previously been detected via linkage mapping in a half-sib design (granddaughter or daughter design), and sires (grandsires) likely to be… CONTINUE READING