Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene.

@article{You2009FineMO,
  title={Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene.},
  author={Ming You and Daolong Wang and Pengyuan Y Liu and Haris G. Vikis and Michael A James and Yan Lu and Yian Wang and Min Wang and Qiong Chen and Dongmei Jia and Yan Liu and Weidong Wen and Ping Yang and Zhifu Sun and Susan Mengel Pinney and Wei Zheng and Xiao-ou Shu and Jirong Long and Yu-tang Gao and Y. P. Xiang and Wong-Ho Chow and Nat Rothman and G. M. van Petersen and Mariza A de Andrade and Yanhong Wu and Julie M Cunningham and Jonathan S. Wiest and Pamela R. Fain and Ann Grossbart Schwartz and Luc Girard and Adi Gazdar and Colette Gaba and Henry Rothschild and Diptasri M. Mandal and Teresa Coons and Juwon Lee and Elena Y. Kupert and Daniela Seminara and J Hsu Minna and Joan E. Bailey-Wilson and Christopher I. Amos and Marshall W. Anderson},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 8},
  pages={2666-74}
}
PURPOSE We have previously mapped a major susceptibility locus influencing familial lung cancer risk to chromosome 6q23-25. However, the causal gene at this locus remains undetermined. In this study, we further refined this locus to identify a single candidate gene, by fine mapping using microsatellite markers and association studies using high-density single nucleotide polymorphisms (SNP). EXPERIMENTAL DESIGN Six multigenerational families with five or more affected members were chosen for… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

References

Publications referenced by this paper.

Similar Papers

Loading similar papers…