Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3

@article{McQuillin2006FineMO,
  title={Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3},
  author={Andrew McQuillin and Nicholas J Bass and Gursharan Kalsi and J. P. Lawrence and Vinay Puri and K. Choudhury and S. D. Detera-Wadleigh and David Curtis and Hugh Malcolm Douglas Gurling},
  journal={Molecular Psychiatry},
  year={2006},
  volume={11},
  pages={134-142}
}
Linkage analyses of bipolar families have confirmed that there is a susceptibility locus near the telomere on chromosome 21q. To fine map this locus we carried out tests of allelic association using 30 genetic markers near the telomere at 21q22.3 in 600 bipolar research subjects and 450 ancestrally matched supernormal control subjects. We found significant allelic association with the microsatellite markers D21S171 (P=0.016) and two closely linked single-nucleotide polymorphisms, rs1556314 (P=0… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Sequencing of sporadic Attention-Deficit Hyperactivity Disorder (ADHD) identifies novel and potentially pathogenic de novo variants and excludes overlap with genes associated with autism spectrum disorder.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics • 2017
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Genome wide scan using homozygosity mapping and linkage analyses of a single pedigree with affective disorder suggests oligogenic inheritance.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics • 2003

A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22.

Proceedings of the National Academy of Sciences of the United States of America • 2001

Similar Papers

Loading similar papers…