Fine mapping of T-cell immunoglobulin mucin domain gene 1 failed to detect a significant association with multiple sclerosis.

@article{Grabmer2010FineMO,
  title={Fine mapping of T-cell immunoglobulin mucin domain gene 1 failed to detect a significant association with multiple sclerosis.},
  author={Christoph Grabmer and Wolfgang Nachbauer and Kathrin Schanda and P Feurle and Klaus Loacker and Elisabeth Scholz and Harald Schennach and Thomas F H Berger and Markus Reindl and Ch Gassner},
  journal={Tissue antigens},
  year={2010},
  volume={75 3},
  pages={235-41}
}
The T-cell immunoglobulin mucin (TIM) gene family encodes receptors on T-cells that regulate Th1- and Th2-cell-mediated immunity. Recently published data implied differential expression of human TIM molecules by mononuclear cells in cerebrospinal fluid of patients with multiple sclerosis (MS) and might therefore be involved in different phases of the pathogenesis of MS. The purpose of this study was to investigate the association of TIM1 gene polymorphism with susceptibility to and clinical… CONTINUE READING