Fine-mapping and candidate gene investigation within the PARK10 locus

  title={Fine-mapping and candidate gene investigation within the PARK10 locus},
  author={K. Haugarvoll and Mathias Toft and L. Skipper and M. Heckman and J. Crook and A. Soto and O. Ross and M. Hulihan and J. Kachergus and S. Sando and L. White and T. Lynch and J. Gibson and R. Uitti and Z. Wszolek and J. Aasly and M. Farrer},
  journal={European Journal of Human Genetics},
  • K. Haugarvoll, Mathias Toft, +14 authors M. Farrer
  • Published 2009
  • Biology, Medicine
  • European Journal of Human Genetics
  • Herein, we investigate whether single-nucleotide polymorphisms (SNPs) across the PARK10 locus are associated with susceptibility to Parkinson's disease (PD) or age at onset (AAO) of disease. One hundred and eighty-eight SNPs were genotyped across the PARK10 locus in 180 PD patients and 180 controls from central Norway (stage 1). We then used the linkage disequilibrium (LD) structure from stage 1 to select 75 SNPs for genotyping in 186 patients and 186 controls from Ireland (stage 2). Nineteen… CONTINUE READING
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