Fine-grained statistical torsion angle potentials are effective in discriminating native protein structures.

@article{Albiero2006FinegrainedST,
  title={Fine-grained statistical torsion angle potentials are effective in discriminating native protein structures.},
  author={Alessandro Albiero and Silvio C. E. Tosatto},
  journal={Current drug discovery technologies},
  year={2006},
  volume={3 1},
  pages={75-81}
}
Modelling of drug targets requires the reliable selection of an accurate and representative structure from large ensembles of alternate models. Statistical potentials developed to discriminate native protein structures generally represent pairwise interactions between atoms, which are less sensitive to local conformational details. The discrimination of local distortions is therefore particularly difficult. Local interaction preferences, expressed through torsion angles, are rarely used, as… CONTINUE READING

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