Fine control of operantly conditioned firing patterns of cortical neurons

  title={Fine control of operantly conditioned firing patterns of cortical neurons},
  author={Edward M. Schmidt and Jr. S. Mcintosh and Luca Durelli and Martin Bak},
  journal={Experimental Neurology},

Operant conditioning reveals task-specific responses of single neurons in a brain–machine interface

The results suggest that thresholded activity single-neuron BMI implementations are more appropriate compared to windowed activity BMI tasks to capitalize on the adaptability of cortical circuits to acquire novel arbitrary skills.

“Master” Neurons Induced by Operant Conditioning in Rat Motor Cortex during a Brain-Machine Interface Task

Modifications during training target preferentially the neuron chosen to control the BMI, which acts then as a “master” neuron, leading in time the reconfiguration of activity in the local cortical network.

Single neuron recording from motor cortex as a possible source of signals for control of external devices

  • E. Schmidt
  • Biology
    Annals of Biomedical Engineering
  • 2006
Improvements are required in electrode design, fabrication, implantation, and signal processing techniques before this method of obtaining control signals would be feasible for human applications, but preliminary studies have been encouraging on obtaining connections to the nervous system to control external devices.

Activity of Neurons in Area 4 and in Area 5 of Monkey During Operant Conditioning of a Flexion Movement

Changes of neuronal activity in Area 4 and Area 5 of macaca Speciosa are concerns during shaping of a self initiated flexion movement of the elbow without sensory cues, and a model to quantify neuronal patterns whose changes are compared with the changes in behavior is proposed.

Rapid acquisition of novel interface control by small ensembles of arbitrarily selected primary motor cortex neurons.

Patterns of voluntarily comodulated firing among small numbers of arbitrarily selected primary motor cortex (M1) neurons thus can be found and improved rapidly, with little constraint based on the normal relationships of the individual neurons to native limb movement.



Operant Conditioning of Specific Patterns of Neural and Muscular Activity

Correlations between a precentral cell and specific arm muscles consistently appeared under several behavioral conditions, but could be dissociated by reinforcing cell activity and muscle suppression.

Operant Conditioning of Cortical Unit Activity

  • E. Fetz
  • Biology, Psychology
  • 1969
The activity of single neurons in precentral cortex of unanesthetized monkeys (Macaca mulatta) was conditioned by reinforcing high rates of neuronal discharge with delivery of a food pellet. Auditory