Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C.

@article{Bonorino2009FineCO,
  title={Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C.},
  author={Paula Bonorino and Muhammad Ramzan and Xavier Camous and Tania Dufeu-Duchesne and M A Th{\'e}lu and Nathalie Sturm and Aur{\'e}lie Dariz and Christiane Guillermet and Martine Pernollet and J J Zarski and Patrice N Marche and Vincent Leroy and Evelyne Jouvin-Marche},
  journal={Journal of hepatology},
  year={2009},
  volume={51 3},
  pages={458-67}
}
BACKGROUND/AIMS The fate of intrahepatic NK cell subsets in the course of HCV and HBV infections is not clearly understood. METHODS Blood and intrahepatic CD56(+) NK cell subsets (expressing NKG2A, CD158a,h or CD158b,j receptors) from HCV or HBV patients were quantified by flow cytometry and localized by immunohistochemistry in liver biopsies. RESULTS A significant reduction in NK cell frequency and a quantitative imbalance between CD56(bright) and CD56(dim) subsets were observed in chronic… CONTINUE READING

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