Fine architecture and mutation mapping of human brain inhibitory system ligand gated ion channels by high-throughput homology modeling.

@article{Mullins2010FineAA,
  title={Fine architecture and mutation mapping of human brain inhibitory system ligand gated ion channels by high-throughput homology modeling.},
  author={Jonathan G. L. Mullins and Seo-Kyung Chung and Mark Ian Rees},
  journal={Advances in protein chemistry and structural biology},
  year={2010},
  volume={80},
  pages={117-52}
}
The common architecture of the brain inhibitory system ligand-gated ion-channels was examined at the level of each of the subunits and in their assembled pentameric arrangements. Structural modeling of the GABAA receptor, GlyR1, and the serotonin receptor, 5HTR3A, was carried out on a multi-homolog basis employing a high-throughput homology modeling… CONTINUE READING