Fine analysis of immunoreactivity of V3 peptides: antibodies specific for V3 domain of laboratory HIV type 1 strains recognize multiple V3 sequences synthesized from field HIV type 1 isolates.

@article{Boudet1996FineAO,
  title={Fine analysis of immunoreactivity of V3 peptides: antibodies specific for V3 domain of laboratory HIV type 1 strains recognize multiple V3 sequences synthesized from field HIV type 1 isolates.},
  author={Francis Boudet and J J Lasarte and Pablo Sarobe and Francisco Borr{\'a}s-Cuesta and Jacques Th{\'e}ze},
  journal={AIDS research and human retroviruses},
  year={1996},
  volume={12 18},
  pages={1671-9}
}
Production of cross-reactive antibodies recognizing the V3 loop--that is, the principal neutralizing determinant (PND)--of various HIV-1 isolates is an important challenge in the development of passive immunotherapy or vaccinations against AIDS. We have produced two types of antibodies to the V3 domain of HIV-1: (1) antibodies against the HIV-1 MN… CONTINUE READING