Fine Tuning of Sympathetic Transmitter Release via Ionotropic and Metabotropic Presynaptic Receptors

@article{Boehm2002FineTO,
  title={Fine Tuning of Sympathetic Transmitter Release via Ionotropic and Metabotropic Presynaptic Receptors},
  author={S. Boehm and H. Kubista},
  journal={Pharmacological Reviews},
  year={2002},
  volume={54},
  pages={43 - 99}
}
The release of transmitters at sympathoeffector junctions is not constant, but subject to modulation by a plethora of different mechanisms. In this respect, presynaptic receptors located on the sympathetic axon terminals are of utmost importance, because they are activated by exogenous agonists and by endogenous neurotransmitters. In the latter case, the transmitters that activate the presynaptic receptors of a nerve terminal may be released either from the very same nerve ending or from a… Expand
Molecular mechanisms underlying the modulation of exocytotic noradrenaline release via presynaptic receptors.
TLDR
This review gives a short overview of the presynaptic receptors on noradrenergic nerve terminals and summarizes the events involved in vesicle exocytosis in order to finally delineate the most important signaling cascades that mediate the modulation via presyaptic receptors. Expand
Human presynaptic receptors.
TLDR
This review will focus on presynaptic receptors in human tissues and the activation of inhibitory α2-adrenoceptors on postganglionic parasympathetic neurons. Expand
Presynaptic ionotropic receptors and control of transmitter release
TLDR
An overview of the presynaptic ionotropic receptors that modulate transmitter release is provided, focusing on their proposed mechanisms of action. Expand
P2 receptor-mediated modulation of neurotransmitter release—an update
TLDR
The rapidly emerging data on the modulation of transmitter release by facilitatory and inhibitory P2 receptors and the receptor subtypes involved in these interactions are reviewed. Expand
Presynaptic neuropeptide receptors.
Presynaptic receptors for four families of neuropeptides will be discussed: opioids, neuropeptide Y, adrenocorticotropic hormone (ACTH), and orexins. Presynaptic receptors for the opioids (micro,Expand
Regulation of neuronal ion channels via P2Y receptors
TLDR
This review summarizes the current knowledge about the modulation of neuronal ion channels via P2Y receptors, and the regulated proteins include voltage-gated Ca2+ and K+ channels, as well as N-methyl-d-aspartate, vanilloid, and P2X receptor subtypes. Expand
Facilitation of transmitter release from rat sympathetic neurons via presynaptic P2Y1 receptors
TLDR
Results show that presynaptic P2y1 receptors mediate facilitation of transmitter release from sympathetic nerve terminals via phospholipase C, and interference with this mechanism by P2Y1 antagonists can be expected to counteract the previously described vasoconstrictive action of these drugs. Expand
Presynaptic inhibition of transmitter release from rat sympathetic neurons by bradykinin
TLDR
It is demonstrated that bradykinin inhibits noradrenaline release from rat sympathetic neurons via presynaptic B2 receptors via an inhibition of voltage‐gated Ca2+ channels. Expand
Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline.
TLDR
Specific knowledge about the function of receptor subtypes will enhance the understanding of the physiological role of the cholinergic and adrenergic nervous system and open new avenues for subtype-selective therapeutic strategies. Expand
Modulation of nicotinic receptor channels by adrenergic stimulation in rat pinealocytes.
TLDR
Results suggest that NE released from sympathetic terminals at night attenuates nicotinic cholinergic signaling, and removal of ATP from the intracellular pipette solution blocked the reduction of nAChR currents, suggesting involvement of protein kinases. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 741 REFERENCES
Acetylcholine at motor nerves: storage, release, and presynaptic modulation by autoreceptors and adrenoceptors.
  • I. Wessler
  • Chemistry, Medicine
  • International review of neurobiology
  • 1992
TLDR
Clear and basic evidence is summarized that the release of acetylcholine from the motor nerve (phrenic nerve) measured by a radiotracer method under the condition of unblocked acetylCholinesterase, which is a crucial condition for the operation of presynaptic nicotine receptors, is regulated by nicotine and muscarine autoreceptors. Expand
Modulation of neural ATP release through presynaptic receptors
Abstract Neural release of ATP can be elicited through or modulated through presynaptic receptors, as is known for classical transmitter substances. Activation of presynaptic nicotinic and serotoninExpand
Presynaptic receptors involved in the modulation of release of noradrenaline from the sympathetic nerve terminals of the rat thymus.
TLDR
A novel, potent and highly selective competitive antagonist of the alpha 2-adrenoreceptor, CH-38083, significantly enhanced the release of NA, suggesting that its release in the thymus is under tonic inhibitory control exerted by endogenously released NA. Expand
The Mechanism of Inhibition of 3H‐Norepinephrine Release by Norepinephrine in Cultured Sympathetic Neurons
TLDR
It is proposed that alpha, agonists directly inhibit C a + + entry without the involvement of K' efflux and thereby inhibit the stimulus-evoked release of 'H-NE' in the guinea pig heart. Expand
P2-receptors controlling neurotransmitter release from postganglionic sympathetic neurones.
TLDR
This chapter discusses the properties and the functional roles of P2-receptors present on postganglionic sympathetic neurons, which have been proposed to be involved in fast synaptic neuro-neural transmission in sympathetic ganglia. Expand
Presynaptic regulation of the release of catecholamines.
TLDR
Evidence has accumulated in favour of the view that, in addition to the classical postsynaptic adrenoceptors that mediate the responses of the effector organ, there are also receptors located on the noradrenergic nerve terminals that appear to be involved in the modulation of the release of dopamine and of epinephrine in the central nervous system. Expand
Axon terminal P2-purinoceptors in feedback control of sympathetic transmitter release
TLDR
It is shown that two P2 antagonists, suramin and Reactive Blue 2, increase the release of noradrenaline in mouse vas deferens and mediate a novel prejunctional negative feedback in which released ATP inhibits subsequent transmitter release. Expand
Presynaptic Receptors and Autonomic Effectors
  • S. Kalsner
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • 1990
TLDR
In the central nervous system the paracrine secretion of transmitter may invoke homoreceptor activation rather than autoreceptors, and it is shown that yohimbine and a low concentration of veratridine have similar and nonadditive effects on transmitter release. Expand
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
TLDR
It is shown that both the α2A- and α2C-subtypes are required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. Expand
α-Adrenergic inhibition of sympathetic neurotransmitter release mediated by modulation of N-type calcium-channel gating
TLDR
This is the first detailed description of inhibition of a high-voltage activated neuronal Ca2+ channel at the single-channel level and the coupling between α-adrenergic receptors and N-type channels involves a G protein, but not a readily diffusible cytoplasmic messenger or protein kinase C, and may be well suited for rapid and spatially localized feedback-control of transmitter release. Expand
...
1
2
3
4
5
...