Fine T-cell subsets in alcoholics as determined by the expression of L-selectin, leukocyte common antigen, and beta-integrin.

@article{Cook1994FineTS,
  title={Fine T-cell subsets in alcoholics as determined by the expression of L-selectin, leukocyte common antigen, and beta-integrin.},
  author={Robert T. Cook and Thomas J Waldschmidt and Zuhair K. Ballas and Brian L. Cook and Brenda M Booth and Brandon Stewart and Michael J. Garvey},
  journal={Alcoholism, clinical and experimental research},
  year={1994},
  volume={18 1},
  pages={
          71-80
        }
}
Alcoholics admitted to the hospital solely for detoxication have been studied by flow cytometry to evaluate changes in the surface markers of peripheral blood leukocytes. As we have shown previously, such patients have an elevated percentage of CD8hi lymphocytes that are HLA DR+; we now demonstrate that they also have striking alterations in the quantitative relationships of the fine T-cell subsets. Both CD4+ and CD8hi lymphocytes have a sharply reduced percentage of the L-selectin+ CD45RA… CONTINUE READING

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Impact of Alcohol Abuse on the Adaptive Immune System.

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