Fine-Scale Signatures of Molecular Evolution Reconcile Models of Indel-Associated Mutation

@inproceedings{Jovelin2013FineScaleSO,
  title={Fine-Scale Signatures of Molecular Evolution Reconcile Models of Indel-Associated Mutation},
  author={Richard Jovelin and Asher D Cutter},
  booktitle={Genome biology and evolution},
  year={2013}
}
Genomic structural alterations that vary within species, known as large copy number variants, represent an unanticipated and abundant source of genetic diversity that associates with variation in gene expression and susceptibility to disease. Even short insertions and deletions (indels) can exert important effects on genomes by locally increasing the mutation rate, with multiple mechanisms proposed to account for this pattern. To better understand how indels promote genome evolution, we… CONTINUE READING
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