Fine Particulate Matter Constituents, Nitric Oxide Synthase DNA Methylation and Exhaled Nitric Oxide.

@article{Chen2015FinePM,
  title={Fine Particulate Matter Constituents, Nitric Oxide Synthase DNA Methylation and Exhaled Nitric Oxide.},
  author={Renjie Chen and Liping Qiao and Huichu Li and Yan Zhao and Yun-hui Zhang and Wenxi Xu and Cuicui Wang and Hongli Wang and Zhuohui Zhao and Xiaohui Xu and Hui Hu and Haidong Kan},
  journal={Environmental science & technology},
  year={2015},
  volume={49 19},
  pages={
          11859-65
        }
}
It remains unknown how fine particulate matter (PM2.5) constituents affect differently the fractional concentration of exhaled nitric oxide (FeNO, a biomarker of airway inflammation) and the DNA methylation of its encoding gene (NOS2A). We aimed to investigate the short-term effects of PM2.5 constituents on NOS2A methylation and FeNO. We designed a longitudinal study among chronic obstructive pulmonary disease (COPD) patients with six repeated health measurements in Shanghai, China. We applied… CONTINUE READING
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