Fine Mapping the Spatial Distribution and Concentration of Unlabeled Drugs within Tissue Micro-Compartments Using Imaging Mass Spectrometry

@inproceedings{Nilsson2010FineMT,
  title={Fine Mapping the Spatial Distribution and Concentration of Unlabeled Drugs within Tissue Micro-Compartments Using Imaging Mass Spectrometry},
  author={Anna Nilsson and Thomas E. Fehniger and Lena Gustavsson and Malin Andersson and Kerstin Kenne and Gy{\"o}rgy Marko-Varga and Per E. Andr{\'e}n},
  booktitle={PloS one},
  year={2010}
}
Readouts that define the physiological distributions of drugs in tissues are an unmet challenge and at best imprecise, but are needed in order to understand both the pharmacokinetic and pharmacodynamic properties associated with efficacy. Here we demonstrate that it is feasible to follow the in vivo transport of unlabeled drugs within specific organ and tissue compartments on a platform that applies MALDI imaging mass spectrometry to tissue sections characterized with high definition histology… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 61 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Mapping pharmaceuticals in tissues using MALDI imaging mass spectrometry.

Journal of pharmacological and toxicological methods • 2007
View 1 Excerpt

The future of SPECT in a time of PET.

Nuclear medicine and biology • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…