Finding weak similarities between proteins by sequence profile comparison.

@article{Panchenko2003FindingWS,
  title={Finding weak similarities between proteins by sequence profile comparison.},
  author={Anna R. Panchenko},
  journal={Nucleic acids research},
  year={2003},
  volume={31 2},
  pages={683-9}
}
To improve the recognition of weak similarities between proteins a method of aligning two sequence profiles is proposed. It is shown that exploring the sequence space in the vicinity of the sequence with unknown properties significantly improves the performance of sequence alignment methods. Consistent with the previous observations the recognition sensitivity and alignment accuracy obtained by a profile-profile alignment method can be as much as 30% higher compared to the sequence-profile… CONTINUE READING

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