Finding the will and the way of ERAD substrate retrotranslocation.

  title={Finding the will and the way of ERAD substrate retrotranslocation.},
  author={Randolph Y. Hampton and Thomas M. Sommer},
  journal={Current opinion in cell biology},
  volume={24 4},
ER-associated degradation (ERAD) is a mechanism by which numerous ER-localized proteins are targeted for cytosolic degradation by the ubiquitin-proteasome system. A surprising and still-cryptic requirement of this process is the energy dependent retrotranslocation of both lumenal and membrane-embedded ER proteins into the cytosol for ongoing ubiquitination and proteasomal destruction. The current understanding, results, and open questions are discussed below for this intriguing and critical… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 53 extracted citations


Publications referenced by this paper.
Showing 1-10 of 76 references

Debose-Boyd RA: Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase

  • Y Jo
  • Crit Rev Biochem Mol Biol
  • 2010
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…