Finding the self by losing the self: Neural correlates of ego‐dissolution under psilocybin

  title={Finding the self by losing the self: Neural correlates of ego‐dissolution under psilocybin},
  author={Alexander V. Lebedev and Martin L{\"o}vd{\'e}n and Gidon Rosenthal and Amanda Feilding and David J. Nutt and Robin Lester Carhart-Harris},
  journal={Human Brain Mapping},
Ego‐disturbances have been a topic in schizophrenia research since the earliest clinical descriptions of the disorder. Manifesting as a feeling that one's “self,” “ego,” or “I” is disintegrating or that the border between one's self and the external world is dissolving, “ego‐disintegration” or “dissolution” is also an important feature of the psychedelic experience, such as is produced by psilocybin (a compound found in “magic mushrooms”). Fifteen healthy subjects took part in this placebo… 
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Contin developments in phenomenology have further incorporated aspects of schizophrenic symptom development and in doing so have brought so-called transitional phenomena and the core schizophrenic syndrome into focus.
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Psilocybin caused a significant decrease in the positive coupling between the mPFC and PCC, which strongly imply that the subjective effects of psychedelic drugs are caused by decreased activity and connectivity in the brain's key connector hubs, enabling a state of unconstrained cognition.
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