Finding the genes in genomic DNA.

@article{Burge1998FindingTG,
  title={Finding the genes in genomic DNA.},
  author={Christopher B. Burge and Samuel Karlin},
  journal={Current opinion in structural biology},
  year={1998},
  volume={8 3},
  pages={346-54}
}
Genome sequencing efforts will soon generate hundreds of millions of bases of human genomic DNA containing thousands of novel genes. In the past year, the accuracy of computational gene-finding methods has improved significantly, to the point where a reasonable approximation of the gene structures within an extended genomic region can often be predicted in advance of more detailed experimental studies. 
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