Finding the engram

@article{Josselyn2015FindingTE,
  title={Finding the engram},
  author={S. Josselyn and S. K{\"o}hler and P. Frankland},
  journal={Nature Reviews Neuroscience},
  year={2015},
  volume={16},
  pages={521-534}
}
Many attempts have been made to localize the physical trace of a memory, or engram, in the brain. However, until recently, engrams have remained largely elusive. In this Review, we develop four defining criteria that enable us to critically assess the recent progress that has been made towards finding the engram. Recent 'capture' studies use novel approaches to tag populations of neurons that are active during memory encoding, thereby allowing these engram-associated neurons to be manipulated… Expand
278 Citations

Figures from this paper

Still searching for the engram
  • 44
  • PDF
Which Neurons Will Be the Engram - Activated Neurons and/or More Excitable Neurons?
  • 8
  • PDF
In Search of Engram Cells
  • 2
From Engrams to Pathologies of the Brain
  • 18
Dynamic and heterogeneous neural ensembles contribute to a memory engram
  • 1
Heroes of the Engram
  • 42
  • PDF
The Emergent Engram: A Historical Legacy and Contemporary Discovery
  • 1
  • Highly Influenced
The role of engram cells in the systems consolidation of memory
  • 110
  • PDF
Manipulating memory in space and time
  • 3
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 222 REFERENCES
Memory Allocation
  • 12
  • PDF
Cognitive Neuroscience and the Study of Memory
  • 1,140
  • PDF
Memory traces unbound
  • K. Nader
  • Chemistry, Medicine
  • Trends in Neurosciences
  • 2003
  • 673
  • PDF
Mechanisms of memory.
  • 958
  • PDF
Pathways of the past: the imprint of memory
  • G. Horn
  • Psychology, Medicine
  • Nature Reviews Neuroscience
  • 2004
  • 224
  • PDF
Identification of a Functional Connectome for Long-Term Fear Memory in Mice
  • 147
  • PDF
The organization of recent and remote memories
  • 1,542
  • PDF
...
1
2
3
4
5
...