Finding the engram

  title={Finding the engram},
  author={Sheena A. Josselyn and Stefan K{\"o}hler and Paul W. Frankland},
  journal={Nature Reviews Neuroscience},
Many attempts have been made to localize the physical trace of a memory, or engram, in the brain. However, until recently, engrams have remained largely elusive. In this Review, we develop four defining criteria that enable us to critically assess the recent progress that has been made towards finding the engram. Recent 'capture' studies use novel approaches to tag populations of neurons that are active during memory encoding, thereby allowing these engram-associated neurons to be manipulated… CONTINUE READING
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