Finding of the endocannabinoid signalling system in Hydra, a very primitive organism: possible role in the feeding response.

@article{Petrocellis1999FindingOT,
  title={Finding of the endocannabinoid signalling system in Hydra, a very primitive organism: possible role in the feeding response.},
  author={Luciano De Petrocellis and Dominique J. Melck and Tiziana Bisogno and Alfredo Milone and Vincenzo Di Marzo},
  journal={Neuroscience},
  year={1999},
  volume={92 1},
  pages={377-87}
}
Hydra (Cnidaria) is the first animal organism to have developed a neural network, which has been proposed to control, inter alia, the "feeding response", i.e. a mechanism through which the coelenterate opens and then closes its mouth in the presence of prey and/or glutathione. Here, we report that Hydra contains: (i) selective cannabinoid binding sites; (ii) the endogenous cannabinoid receptor ligand, anandamide (arachidonoylethanolamide); (iii) a fatty acid amide hydrolase-like activity… CONTINUE READING
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