Finding important sites in protein sequences.

  title={Finding important sites in protein sequences.},
  author={Peter J. Bickel and Katherina J Kechris and Philip C Spector and Gary J. Wedemayer and Alexander N. Glazer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={99 23},
By using sequence information from an aligned protein family, a procedure is exhibited for finding sites that may be functionally or structurally critical to the protein. Features based on sequence conservation within subfamilies in the alignment and associations between sites are used to select the sites. The sites are subject to statistical evaluation correcting for phylogenetic bias in the collection of sequences. This method is applied to two families: the phycobiliproteins, light… CONTINUE READING