Finding disease-specific coordinated functions by multi-function genes: insight into the coordination mechanisms in diseases.

Abstract

We developed an approach using multi-function disease genes to find function pairs whose co-deregulation might induce a disease. Analyzing cancer genes, we found many cancer-specific coordinated function pairs co-deregulated by dysfunction of multi-function genes and other molecular changes in cancer. Studying two subtypes of cardiomyopathy, we found they… (More)
DOI: 10.1016/j.ygeno.2009.05.001

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