Finasteride in the treatment of alopecia

@article{Libecco2004FinasterideIT,
  title={Finasteride in the treatment of alopecia},
  author={James F Libecco and Wilma Fowler Bergfeld},
  journal={Expert Opinion on Pharmacotherapy},
  year={2004},
  volume={5},
  pages={933 - 940}
}
Finasteride is a 5α-reductase inhibitor approved for the treatment of male pattern hair loss. Originally approved for the treatment of benign prostatic hypertrophy in 1992, its approval was expanded in 1997 to include the treatment of androgenetic alopecia (AGA) in men at a dose of 1 mg/day. Finasteride inhibits 5α-reductase, thereby prohibiting the conversion of testosterone to dihydrotestosterone (DHT), which is implicated in the development of hairless in some men. Reduction in DHT results… 
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References

SHOWING 1-10 OF 66 REFERENCES
Topical finasteride in the treatment of androgenic alopecia. Preliminary evaluations after a 16-month therapy course
TLDR
The clinical outcome, in terms of both hair regrowth and balding areas reduction, seems to be encouraging, in the absence of either any evidence of percutaneous absorption of finasteride, or local/systemic untoward effects.
Lack of efficacy of finasteride in postmenopausal women with androgenetic alopecia.
TLDR
In postmenopausal women with AGA, finasteride 1 mg/day taken for 12 months did not not increase hair growth or slow the progression of hair thinning.
Finasteride: a review of its use in male pattern hair loss.
TLDR
Oral finasteride promotes scalp hair growth and prevents further hair loss in a significant proportion of men with male pattern hair loss, and is a new approach to the management of this condition, for which treatment options are few.
Finasteride in the treatment of men with frontal male pattern hair loss.
Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group.
Hair loss in women with hyperandrogenism: four cases responding to finasteride.
TLDR
The finding that finasteride treatment improves pattern hair loss in women with hyperandrogenism but does not affect those postmenopausal women with female patternhair loss without hyperandrogensism supports the concept that not all types of female hair loss have the same pathophysiology.
Finasteride in the treatment of hirsutism: new therapeutic perspectives.
Chronic treatment with finasteride daily does not affect spermatogenesis or semen production in young men.
Finasteride increases anagen hair in men with androgenetic alopecia
TLDR
Evidence is provided that finasteride treatment results in favourable effects on hair quality that contribute to the visible improvements in hair growth observed in treated patients and provides direct evidence thatfinasteride 1 mg daily promotes the conversion of hairs into the anagen phase.
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