Finasteride‐induced depression: new insights into possible pathomechanisms

  title={Finasteride‐induced depression: new insights into possible pathomechanisms},
  author={B. R{\"o}mer and P. Gass},
  journal={Journal of Cosmetic Dermatology},
  • B. Römer, P. Gass
  • Published 2010
  • Medicine
  • Journal of Cosmetic Dermatology
  • 5‐alpha‐reductase is involved as a rate‐imitating enzyme in the metabolism of steroids. Several 5‐alpha‐reduced steroids such as dihydrotestosterone, allopregnanolone or tetrahydrocorticosterone have neurotrophic, neuroprotective, and anxiolytic properties. Reduced 5‐alpha‐reductase activity has been observed during depressive illness in humans. Finasteride inhibits 5‐alpha‐reductase and can robustly induce anxious and depressive behaviors in rodents. In humans finasteride treatment has been… CONTINUE READING
    22 Citations
    Post-finasteride syndrome: An emerging clinical problem
    • 8
    Neuroactive steroids in affective disorders: target for novel antidepressant or anxiolytic drugs?
    • 106
    Post-finasteride syndrome – does it really exist?
    • 3
    Emotional Consequences of Finasteride: Fool’s Gold
    • 21


    Finasteride treatment inhibits adult hippocampal neurogenesis in male mice.
    • 29
    Finasteride: the first 5 alpha-reductase inhibitor.
    • 51
    A new look at the 5alpha-reductase inhibitor finasteride.
    • 113
    Neurosteroids: endogenous regulators of the GABAA receptor
    • 924
    Steroids, neuroactive steroids and neurosteroids in psychopathology
    • B. Dubrovsky
    • Chemistry, Medicine
    • Progress in Neuro-Psychopharmacology and Biological Psychiatry
    • 2005
    • 225