Finasteride‐induced depression: new insights into possible pathomechanisms

@article{Rmer2010FinasterideinducedDN,
  title={Finasteride‐induced depression: new insights into possible pathomechanisms},
  author={Benedikt R{\"o}mer and Peter Gass},
  journal={Journal of Cosmetic Dermatology},
  year={2010},
  volume={9}
}
  • B. Römer, P. Gass
  • Published 1 December 2010
  • Biology, Psychology
  • Journal of Cosmetic Dermatology
5‐alpha‐reductase is involved as a rate‐imitating enzyme in the metabolism of steroids. Several 5‐alpha‐reduced steroids such as dihydrotestosterone, allopregnanolone or tetrahydrocorticosterone have neurotrophic, neuroprotective, and anxiolytic properties. Reduced 5‐alpha‐reductase activity has been observed during depressive illness in humans. Finasteride inhibits 5‐alpha‐reductase and can robustly induce anxious and depressive behaviors in rodents. In humans finasteride treatment has been… 
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Data indicate that inhibition of 5-alpha-reductase activity by finasteride treatment influences neuronal plasticity on a structural level, which might contribute to the pathophysiology of depressive episodes observed after finasterid treatment.
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This preliminary study suggests that finasteride might induce depressive symptoms; therefore this medication should be prescribed cautiously for patients with high risk of depression.
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Its efficacy in regression of prostate gland enlargement is rapid and predictable, although correlation with subsequent improvement in urinary flow and symptoms is highly variable, and finasteride may hold promise for other DHT‐mediated disorders such as acne, facial hirsutism, frontal lobe alopecia, and prostate cancer, but its use in these conditions remains investigational.
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Its efficacy in regression of prostate gland enlargement is rapid and predictable, although correlation with subsequent improvement in urinary flow and symptoms is highly variable, and finasteride may hold promise for other DHT-mediated disorders such as acne, facial hirsutism, frontal lobe alopecia, and prostate cancer, but its use in these conditions remains investigational.
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