Finasteride‐induced depression: new insights into possible pathomechanisms

@article{Rmer2010FinasterideinducedDN,
  title={Finasteride‐induced depression: new insights into possible pathomechanisms},
  author={B. R{\"o}mer and P. Gass},
  journal={Journal of Cosmetic Dermatology},
  year={2010},
  volume={9}
}
  • B. Römer, P. Gass
  • Published 2010
  • Medicine
  • Journal of Cosmetic Dermatology
    • 5‐alpha‐reductase is involved as a rate‐imitating enzyme in the metabolism of steroids. Several 5‐alpha‐reduced steroids such as dihydrotestosterone, allopregnanolone or tetrahydrocorticosterone have neurotrophic, neuroprotective, and anxiolytic properties. Reduced 5‐alpha‐reductase activity has been observed during depressive illness in humans. Finasteride inhibits 5‐alpha‐reductase and can robustly induce anxious and depressive behaviors in rodents. In humans finasteride treatment has been… CONTINUE READING
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    22 Citations
    Background Citations
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    Results Citations
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    22 Citations
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