Finasteride: a slow-binding 5 alpha-reductase inhibitor.

@article{Faller1993FinasterideAS,
  title={Finasteride: a slow-binding 5 alpha-reductase inhibitor.},
  author={Bernard Faller and David Farley and Harry Nick},
  journal={Biochemistry},
  year={1993},
  volume={32 21},
  pages={5705-10}
}
A microsomal preparation of human prostatic tissue was used to study the kinetics of interaction of steroid 5 alpha-reductase with finasteride, a known 5 alpha-reductase inhibitor. This molecule has been reported to reversibly bind 5 alpha-reductase in a competitive manner to testosterone with a Ki value in the 10 nM range. The results presented in this paper show that enzyme-inhibitor complex formation does not take place instantaneously as assumed in previous studies. At neutral pH and 37… CONTINUE READING