Final results of a phase III randomized study of concurrent weekly cisplatin-RT versus RT alone in locoregionally advanced nasopharyngeal carcinoma (NPC).

@article{Chan2004FinalRO,
  title={Final results of a phase III randomized study of concurrent weekly cisplatin-RT versus RT alone in locoregionally advanced nasopharyngeal carcinoma (NPC).},
  author={Anthony T. C. Chan and Roger Kai-cheong Ngan and Peter Man Lung Teo and Sing-fai Leung and Hellene Y M Yiu and Winnie Yeo and Tony Shu Kam Mok and Frances Ka Yin Cheung and Wing-hong Kwan and Benny Chung Ying Zee},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2004},
  volume={22 14_suppl},
  pages={5523}
}
5523 Background/Objective: NPC is highly radiosensitive and chemosensitive. 3 cycles of 3-weekly chemotherapy concurrent with RT followed by 3 cycles of adjuvant chemotherapy has improved survival over RT alone in a previous randomized study. The regimen was associated with significant toxicities. This randomized phase III study compared concurrent weekly cisplatin-RT with RT alone in patients with locoregionally advanced NPC. METHODS Patients with Ho's N2 or N3 stage or N1 stage with nodal… CONTINUE READING