Final results of a phase I-II trial using ex vivo expanded autologous Mesenchymal Stromal Cells for the treatment of osteoarthritis of the knee confirming safety and suggesting cartilage regeneration.

@article{Soler2016FinalRO,
  title={Final results of a phase I-II trial using ex vivo expanded autologous Mesenchymal Stromal Cells for the treatment of osteoarthritis of the knee confirming safety and suggesting cartilage regeneration.},
  author={Robert R Soler and Llu{\'i}s Orozco and Ana Munar and Marina Huguet and R. M. Casado L{\'o}pez and Joaquim Vives and Ruth Coll and Margarita Codinach and Joan Garc{\'i}a-L{\'o}pez},
  journal={The Knee},
  year={2016},
  volume={23 4},
  pages={647-54}
}
BACKGROUND Cellular therapies have shown encouraging results in the treatment of chronic osteoarthritis (OA). Herein, we present the final results of a phase I-II clinical trial assessing the feasibility, safety and efficacy of ex vivo expanded autologous bone marrow Mesenchymal Stromal Cells (MSC, XCEL-M-ALPHA), infused intra-articularly, in patients with knee OA. METHODS Fifteen patients (median age=52years) with grade II(9) or III(6) gonarthrosis (Kellgren & Lawrence classification) and… CONTINUE READING
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