Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury—outcomes at 6 months

@article{Edwards2005FinalRO,
  title={Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury—outcomes at 6 months},
  author={P. Edwards and M. Arango and Laura Balica and R. Cottingham and H. El-Sayed and B. Farrell and J. Fernandes and Tamar Gogichaisvili and N. Golden and B. Hartzenberg and M. Husain and M. I. Ulloa and Z. Jerbi and H. Khamis and E. Komolafe and V. Lalo{\"e} and G. Lomas and S. Ludwig and G. Mazairac and M. A. Mu{\~n}oz S{\'a}nchez and L. Nasi and F. Olldashi and P. Plunkett and I. Roberts and P. Sandercock and H. Shakur and Caridad Soler and R. Stocker and P. Svoboda and S. Trenkler and N. Venkataramana and J. Wasserberg and D. Yates and Surakrant Yutthakasemsunt},
  journal={The Lancet},
  year={2005},
  volume={365},
  pages={1957-1959}
}
MRC CRASH is a randomised controlled trial (ISRCTN74459797) of the effect of corticosteroids on death and disability after head injury. We randomly allocated 10,008 adults with head injury and a Glasgow Coma Scale score of 14 or less, within 8 h of injury, to a 48-h infusion of corticosteroid (methylprednisolone) or placebo. Data at 6 months were obtained for 9673 (96.7%) patients. The risk of death was higher in the corticosteroid group than in the placebo group (1248 [25.7%] vs 1075 [22.3… Expand
Corticosteroids for acute traumatic brain injury.
Steroids and Survival in Critically Ill Adult Patients: A Meta-analysis of 135 Randomized Trials.
Effect of prior statin use on outcome after severe traumatic brain injury in a South-East Asian population
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