Final report of a randomized trial on altered-fractionated radiotherapy in nasopharyngeal carcinoma prematurely terminated by significant increase in neurologic complications.

@article{Teo2000FinalRO,
  title={Final report of a randomized trial on altered-fractionated radiotherapy in nasopharyngeal carcinoma prematurely terminated by significant increase in neurologic complications.},
  author={Peter Man Lung Teo and Sing-fai Leung and Anthony Tak Cheung Chan and To Wai Leung and Peter H K Choi and Wing Hong Kwan and Woo Yong Lee and Ricky Ming-chun Chau and Peter K. N. Yu and Philip James Johnson},
  journal={International journal of radiation oncology, biology, physics},
  year={2000},
  volume={48 5},
  pages={1311-22}
}
PURPOSE The aim of the present study was to compare the survival, local control and complications of conventional/accelerated-hyperfractionated radiotherapy and conventional radiotherapy in nonmetastatic nasopharyngeal carcinoma (NPC). METHODS AND MATERIALS From February 1993 to October 1995, 159 patients with newly diagnosed nonmetastatic (M0) NPC with N0 or 4 cm or less N1 disease (Ho's N-stage classification, 1978) were randomized to receive either conventional radiotherapy (Arm I, n = 82… CONTINUE READING

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