Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products.

@article{2008FinalAR,
  title={Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products.},
  author={},
  journal={International journal of toxicology},
  year={2008},
  volume={27 Suppl 4},
  pages={1-82}
}
Parabens is the name given to a group of p-hydroxybenzoic acid (PHBA) esters used in over 22,000 cosmetics as preservatives at concentrations up to 0.8% (mixtures of parabens) or up to 0.4% (single paraben). The group includes Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben. Industry estimates of the daily use of cosmetic products that may contain parabens were 17.76 g for adults and 378 mg for infants. Parabens in cosmetic… CONTINUE READING

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Epididymis and seminal vesicle weight decreases were reported in rats given a 1% oral Butylparaben dose ; and decreased sperm number and motile activity in F(1 ) offspring of rats maternally exposed to 100 mg / kg day(- 1 ) were reported .
Epididymis and seminal vesicle weight decreases were reported in rats given a 1% oral Butylparaben dose ; and decreased sperm number and motile activity in F(1 ) offspring of rats maternally exposed to 100 mg / kg day(- 1 ) were reported .
EpididymisSibling in part ofSeminal Vesicles
Epididymis and seminal vesicle weight decreases were reported in rats given a 1% oral Butylparaben dose ; and decreased sperm number and motile activity in F(1 ) offspring of rats maternally exposed to 100 mg / kg day(- 1 ) were reported .
Seminal VesiclesSibling in part ofEpididymis
Epididymis and seminal vesicle weight decreases were reported in rats given a 1% oral Butylparaben dose ; and decreased sperm number and motile activity in F(1 ) offspring of rats maternally exposed to 100 mg / kg day(- 1 ) were reported .
Epididymis and seminal vesicle weight decreases were reported in rats given a 1% oral Butylparaben dose ; and decreased sperm number and motile activity in F(1 ) offspring of rats maternally exposed to 100 mg / kg day(- 1 ) were reported .
Epididymis and seminal vesicle weight decreases were reported in rats given a 1% oral Butylparaben dose ; and decreased sperm number and motile activity in F(1 ) offspring of rats maternally exposed to 100 mg / kg day(- 1 ) were reported .
Parabens is the name given to a group of p - hydroxybenzoic acid ( PHBA ) esters used in over 22,000 cosmetics as preservatives at concentrations up to 0.8% ( mixtures of parabens ) or up to 0.4% ( single paraben ) .
Parabens is the name given to a group of p - hydroxybenzoic acid ( PHBA ) esters used in over 22,000 cosmetics as preservatives at concentrations up to 0.8% ( mixtures of parabens ) or up to 0.4% ( single paraben ) .
EstradiolContraindicated with diseaseMammary Neoplasms
Estrogenic activity of parabens and PHBA was increased in human breast cancer cells in vitro , but the increases were around 4 orders of magnitude less than that produced by estradiol .
Numerous genotoxicity studies , including Ames testing , dominant lethal assay , host - mediated assay , and cytogenic assays , indicate that the Parabens are generally nonmutagenic , although Ethylparaben and Methylparaben did increase chromosomal aberrations in a Chinese Hamster ovary cell assay .
Numerous genotoxicity studies , including Ames testing , dominant lethal assay , host - mediated assay , and cytogenic assays , indicate that the Parabens are generally nonmutagenic , although Ethylparaben and Methylparaben did increase chromosomal aberrations in a Chinese Hamster ovary cell assay .
Numerous genotoxicity studies , including Ames testing , dominant lethal assay , host - mediated assay , and cytogenic assays , indicate that the Parabens are generally nonmutagenic , although Ethylparaben and Methylparaben did increase chromosomal aberrations in a Chinese Hamster ovary cell assay .
The Expert Panel considers that these MOS determinations are conservative and likely represent an overestimate of the possibility of an adverse effect ( e.g. , use concentrations may be lower , penetration may be less ) and support the safety of cosmetic products in which parabens preservatives are used .
The CIR Expert Panel considered exposures to cosmetic products containing a single parabens preservative ( use level of 0.4% ) separately from products containing multiple parabens ( use level of 0.8% ) and infant exposures separately from adult exposures in determining margins of safety ( MOS ) .
The CIR Expert Panel considered exposures to cosmetic products containing a single parabens preservative ( use level of 0.4% ) separately from products containing multiple parabens ( use level of 0.8% ) and infant exposures separately from adult exposures in determining margins of safety ( MOS ) .
Parabens is the name given to a group of p - hydroxybenzoic acid ( PHBA ) esters used in over 22,000 cosmetics as preservatives at concentrations up to 0.8% ( mixtures of parabens ) or up to 0.4% ( single paraben ) .
Parabens is the name given to a group of p - hydroxybenzoic acid ( PHBA ) esters used in over 22,000 cosmetics as preservatives at concentrations up to 0.8% ( mixtures of parabens ) or up to 0.4% ( single paraben ) .
Parabens is the name given to a group of p - hydroxybenzoic acid ( PHBA ) esters used in over 22,000 cosmetics as preservatives at concentrations up to 0.8% ( mixtures of parabens ) or up to 0.4% ( single paraben ) .
Numerous genotoxicity studies , including Ames testing , dominant lethal assay , host - mediated assay , and cytogenic assays , indicate that the Parabens are generally nonmutagenic , although Ethylparaben and Methylparaben did increase chromosomal aberrations in a Chinese Hamster ovary cell assay .
Numerous genotoxicity studies , including Ames testing , dominant lethal assay , host - mediated assay , and cytogenic assays , indicate that the Parabens are generally nonmutagenic , although Ethylparaben and Methylparaben did increase chromosomal aberrations in a Chinese Hamster ovary cell assay .
Numerous genotoxicity studies , including Ames testing , dominant lethal assay , host - mediated assay , and cytogenic assays , indicate that the Parabens are generally nonmutagenic , although Ethylparaben and Methylparaben did increase chromosomal aberrations in a Chinese Hamster ovary cell assay .
Estrogenic activity of parabens and PHBA was increased in human breast cancer cells in vitro , but the increases were around 4 orders of magnitude less than that produced by estradiol .
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